在可卡因使用障碍的药物治疗试验中渴望和使用可卡因:多轨迹分析
在PubMed上查看摘要
概括
此摘要是机器生成的。减少可卡因渴望和使用与治疗可卡因使用障碍的更好结果有关. 渴望和使用量下降的参与者在药物和酒精使用,精神状况和人际关系方面显著改善.
科学领域
- 药物成
- 心理药理学
- 临床试验
背景情况
- 在兴奋剂使用障碍治疗期间对可卡因渴望轨迹的研究有限.
- 了解这些轨迹对于评估药物疗法的有效性至关重要.
研究的目的
- 在药物治疗试验中研究可卡因渴望和使用的联合轨迹.
- 评估这些轨迹与心理社会结果的关联.
主要方法
- 在6项随机对照试验中,对1070名参与者的数据进行了多轨迹建模.
- 分析了每周的可卡因渴望和使用量.
- 评估了与成严重程度指数 (ASI) 的相关性.
主要成果
- 确定了三个不同的轨迹:高渴望/高使用率 (40.0%),低渴望/高使用率 (36.8%),低渴望/低使用率 (23.2%).
- 与高欲望/高使用组相比,减少渴望/减少使用组在ASI领域显著改善,包括药物使用,酒精使用,精神状态和关系.
- 与安慰剂相比,modafinil (200mg/天) 与降低渴望/减少使用或降低渴望/高使用组的可能性更高.
结论
- 在治疗试验中的可卡因渴望和使用轨迹是异质的.
- 减少可卡因的渴望和使用是临床相关的结果,与改善的心理社会功能相关.
- 这些发现支持在可卡因使用障碍的药物治疗试验中监测渴望和减少使用的有用性.
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