固定剂量组合使用与药物坚持,医疗保健利用和医疗补助受益者成本之间的关联
Donglan Zhang1, Jun Soo Lee2, Nicole L Therrien2
1Center for Population Health and Health Services Research, Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
固定剂量组合 (FDC) 药物可以改善患者的服药能力,降低医疗费用. 然而,种族差异仍然存在,需要针对性干预以更好地管理高血压.
科学领域:
- 心血管医学
- 医疗服务研究
- 药物经济学
背景情况:
- 与多个单独的药物相比,固定剂量组合 (FDC) 抗高血压药提供了一个简单的治疗方案.
- 尽管有潜在的益处,但FDC抗高血压剂的使用仍然不足.
研究的目的:
- 评估FDC抗高血压疗法与药物坚持,医疗保健利用和成本之间的关联.
- 研究FDC疗法的潜力,以减少药物坚持的种族和民族差异.
主要方法:
- 对2017-2021年Merative MarketScan医疗补助数据库的回顾性队列分析.
- 包括18至64岁的高血压成年人,需要连续注册一年的前后指数日期.
- 倾向性得分重叠以平衡组合药片和多药片治疗组之间的共变量.
主要成果:
- 药物组合治疗与更高的药物坚持 (MPR: 3.17) 以及与高血压相关的急诊和住院减少有关.
- 药剂组合疗法节省了大量的费用, 平均每人2862美元.
- 尽管有好处,但种族和民族之间的药物坚持差异仍然存在.
结论:
- FDC抗高血压疗法为改善高血压管理和减少医疗保健计划和患者的医疗费用提供了可行的策略.
- 解决持续存在的种族和民族差异对于药物治疗至关重要, 需要制定定制的干预措施.
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