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Updated: Sep 10, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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糖屏蔽使得TCR充足的全基性CAR-T疗法成为可能

Zeguang Wu1, Jinhong Shi2, Qiezhong Lamao1

  • 1Biomedical Pioneering Innovation Center, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing 100871, China; Changping Laboratory, Beijing 102206, China.

Cell
|August 22, 2025
PubMed
概括

在T细胞中信号类3 (SPPL3) 缺失促进了对全基性CAR- T治疗的免疫逃避. 这种策略增强了CAR-T细胞的持久性,并减少了排斥,显示出对通用治疗的希望.

关键词:
一个CAR-T单元激活诱导的细胞死亡异种免疫全基因组的CRISPR选甘氨酸移植对宿主疾病主体与移植自然杀手细胞复发性/耐火性B-NHL信号类酶3

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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