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Updated: May 8, 2026

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通过计算解决的神经发育细胞生物标志物与人类疾病相关

Gerarda Cappuccio1, William T Choi2, Fatih Semerci2

  • 1Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

Stem cell reports
|August 22, 2025
PubMed
概括

研究人员使用一种新的计算方法在成年神经干细胞和原生细胞 (NPC) 中确定了关键基因. 这一发现揭示了大脑发育和神经疾病的机制.

关键词:
孟德尔病牙状转数字分类基因发现神经干细胞神经发生神经增生剂没有诊断的疾病

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...