相关实验视频

Updated: May 6, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

对重复磁共振引导的聚焦超声波的微血管和星体反应

Sébastien Rigollet¹, Aurélien Delphin², Lucie Chalet³

¹Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut des Neurosciences, 38000 Grenoble, France; Image Guided Therapy, Pessac, France.

Journal of controlled release : official journal of the Controlled Release Society

|August 22, 2025

概括

用微气泡重复聚焦超声波 (FUS) 可以打开血脑屏障 (BBB) 进行药物输送. 每周一次的FUS是可行的,但每两周一次的治疗可能会导致累积的质和血管变化,需要优化方案.

科学领域:

神经科学
生物医学工程
药理学

背景情况:

使用微气泡的聚焦超声波 (FUS) 通过短暂的血脑屏障 (BBB) 开放,促进了药物的向输送.
使用FUS重复BBB透的长期安全性和神经血管效应尚未完全理解.

研究的目的:

在重复FUS介导的BBB开放后,对健康大鼠的血管,微观结构和质反应进行纵向评估.
评估不同FUS频率和治疗方案对神经血管完整性的影响.

主要方法:

在大鼠中,在390 kPa和440 kPa的声压下,每周或每周两次重复进行FUS.
用磁共振 (MR) 指导定位和MR血管指纹,包括DCE-MRI进行评估.
进行了组织学分析 (GFAP免疫染色) 来评估星球细胞激活.

主要成果:

通过稳定的对比度增强,并且没有检测到出血或.
在每次FUS治疗后,脑血流的短暂减少 (15 - 20%) 被观察到.
每两周一次的FUS在440kPa引起了微妙的血管改造 (血管半径增加,氧和降低) 和显著的星球细胞激活.

结论:

在中等声压下每周FUS诱导的BBB开放是可行的,短期内是安全的.
每两周一次的FUS治疗可能会导致累积的神经免疫反应和血管变化.
在长期治疗中,优化FUS方案对于减轻质和血管应激至关重要.

关键词:

聚焦式超声波通过指纹检测神经炎症输血定量核磁共振

更多相关视频

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

Published on: March 13, 2012

$MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor$ 05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

相关概念视频

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Imaging Studies II: Ultrasonography

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...