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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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在B型肝炎病毒囊组装调节器的计算开发方面取得的进展

Ke Liu1, Shaoqing Du2, Weiqiao Deng3

  • 1School of Chemistry and Chemical Engineering, Linyi University, Linyi, Shandong 276000, China; School of Chemistry and Chemical Engineering, Shandong University, Qingdao, Shandong 266237, China.

Drug discovery today
|August 22, 2025
PubMed
概括

乙型肝炎病毒 (HBV) 囊组合调节器 (CAM) 是抑制病毒复制的关键. 这篇文章强调了计算机辅助药物设计策略,以开发有效的CAM来治疗HBV.

关键词:
体组装调节器体蛋白质计算机辅助药物设计乙型肝炎病毒

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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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