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Updated: Sep 10, 2025

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
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对Streptomyces菌株的泛反应组分析显示了初级和二级新陈代谢之间的关联和断开

Byung Tae Lee1, Omkar S Mohite2, Mun Su Kwon1

  • 1Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon, 34141, Republic of Korea.

Metabolic engineering
|August 22, 2025
PubMed
概括

这项研究分析了242种Streptomyces菌株,揭示了初级和二级新陈代谢之间的联系和差距. 在某些菌株中发现有价值化合物的关键前体是不可生产的,影响了生物合成.

关键词:
生物合成基因集群基因组规模的代谢模型代谢失联全反应体分析二次代谢物斑点菌种

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Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
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