心肌工作指数作为心脏功能的指标
Dorothee Brunet1, Simon Dang Van2, Martin Klockner1
1Department of Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
现场心脏输液 (ESHP) 允许评估可行性. 通过心声学测量的心肌工作指数 (MWI) 与ESHP期间的心脏表现有很强的相关性,支持新平台的开发.
科学领域:
- 心血管外科
- 移植医学
- 医疗器械
背景情况:
- 缺少器官需要使用边缘心脏移植.
- 目前的外置心脏输液 (ESHP) 方法缺乏功能可行性评估.
- 心声学提供了非侵入性评估的潜力.
研究的目的:
- 在ESHP期间调查心脏表现与心肌功能指数 (MWI) 之间的关系.
- 评估ESHP中非侵入性心声学评估的可行性.
主要方法:
- 18个猪心被分为冷藏,低温 perfusion 和循环死亡组.
- 使用工作模式设置进行Normothermic ESHP.
- 使用心声学测量心脏输出和MWI.
主要成果:
- 在两组之间观察到心脏输出和MWI的显著差异 (p<0. 012).
- MWI与心脏输出有很强的正相关性 (r=0. 85, p<0. 001).
- 在ESHP期间对MWI进行心声评估是可行的.
结论:
- 在ESHP期间,MWI是心脏表现的可靠指标.
- 这些发现支持开发具有工作模式能力的集成ESHP平台.
- 需要进一步的研究,包括移植后的数据.
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