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Updated: Sep 10, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth
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通过MGK-264对小鼠肝脏瘤形成的作用分析和人类相关性

Junji Yano1, Kensuke Kawamoto1, Yukako Shimotsuma1

  • 1Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.

Regulatory toxicology and pharmacology : RTP
|August 22, 2025
PubMed
概括

MGK-264是一种杀虫协同剂,在小鼠中激活构成性安德罗斯坦受体 (CAR),导致肝脏瘤. 这种机制不被认为与人类相关,得到人类流行病学研究的支持.

关键词:
构成性安德罗斯坦受体人类相关性肝脏瘤MGK-264 其他作用方式PXB小鼠

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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