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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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相关实验视频

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Teprotumumab 降低了皮质纤维细胞的增殖和活力

Stephen Richard1, Basel Obied2, Jawad Abu-Dbai3

  • 1The Krieger Eye Research Laboratory, Bruce and Ruth Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.

Experimental eye research
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概括
此摘要是机器生成的。

德穆马布 (TPT) 显著降低了人纤维细胞的活力和增殖,显示为一种新的治疗方法. 这种抗纤维作用可以解决术后复发的挑战.

关键词:
纤维细胞增殖人类体纤维细胞类动物德普鲁马布

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科学领域:

  • 眼科 眼科
  • 细胞生物学
  • 药理学

背景情况:

  • 是一种常见的眼部表面疾病,没有有效的医疗治疗方法.
  • 术后的肺复发是一个重大的临床挑战.

研究的目的:

  • 研究类似胰岛素的增长因子1受体抗剂teprotumumab (TPT) 对人纤维细胞 (HPF) 的抗纤维作用.
  • 评估TPT对HPF活力,增殖,DNA损伤和基因表达的影响.

主要方法:

  • 从患者组织中确定的初级人纤维细胞系 (HPF).
  • 用teprotumumab (TPT) 治疗的HPF和评估细胞活力和增殖.
  • 使用道染色,电子显微镜和定量PCR分析DNA损伤和基因表达变化.

主要成果:

  • TPT显著降低了HPF的生存率 (29.5% - 50%) 和增殖率 (32% - 67%).
  • TPT诱导了DNA损伤和改变基因表达,降低了FGF2,VEGFA和PAI-1,同时增加了MMP2和MMP3.
  • 观察到Ki-67阳性细胞显著减少,表明增殖减少.

结论:

  • 在人纤维细胞上表现出强烈的抗纤维作用.
  • TPT 具有治疗的潜力,可能会减少复发和进展.
  • 需要进一步的体内和临床研究来证实TPT在瘤治疗中的有效性和安全性.