相关实验视频

Updated: Sep 10, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

多种组合分析确定瘤细胞衍生的MIF作为治疗点,并加强骨髓瘤中抗PD-1疗法

Weidong Chen^1,2, Yan Liao^1,2, Hao Yao^1,2

¹Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Journal for immunotherapy of cancer

|August 22, 2025

概括

这项研究揭示了乳酸通过调节巨移动抑制因子 (MIF) 通过组织蛋白乳化影响骨肉瘤的进展. 针对MIF增强了抗编程细胞死亡1 (PD-1) 治疗的疗效.

科学领域:

癌症学
癌症新陈代谢
免疫疗法

背景情况:

骨肉瘤是一种具有有限治疗选择的侵袭性骨癌.
多组学分析提供了识别新型治疗点的潜力.
这项研究旨在通过整合多经济学数据开发风险模型并确定目标.

研究的目的:

为了利用多组学整合新型骨肉瘤风险模型.
描述免疫特征并发现治疗点.
研究乳酸和巨细胞迁移抑制因子 (MIF) 在骨肉瘤中的作用.

主要方法:

多基因分析 (代谢学,转录学) 和预后基因鉴定.
免疫细胞透的生物信息分析 (ESTIMATE,xCell) 和单细胞RNA测序.
在体外和体内验证巨细胞迁移抑制因子 (MIF) 抑制和组合治疗.

主要成果:

乳酸水平升高与骨肉瘤存活率降低相关.
基于SLC7A7和CYP27A1分层患者的预后风险模型.
乳酸通过基因素乳化调节MIF,影响巨细胞极化和化学反应;联合MIF抑制和抗PD-1治疗显示出显著的抗瘤作用.

结论:

大细胞迁移抑制因子 (MIF) 是骨肉瘤的新治疗点.
基斯乳化调节乳酸对MIF的表达.
向MIF可以增强抗编程细胞死亡1 (PD-1) 免疫治疗的疗效.

关键词:

骨癌症免疫调节免疫疗法巨细胞

更多相关视频

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...