在冠状动脉疾病患者进行内镜检查时,高流量鼻氧治疗对心脏循环效率的影响:随机对照试验的研究方案
Fang Xie1, Mu Jin1, Tingting Ma1
1Department of Anesthesiology, Beijing An Zhen Hospital, Chaoyang-qu, Beijing, China.
BMJ open
|August 22, 2025
概括
在冠状动脉疾病患者的深静止内镜中,高流量鼻氧疗法 (HFNO) 可能改善心脏功能. 本研究将HFNO与标准氧疗法 (SOT) 进行比较,以评估心肌氧供需平衡.
科学领域:
- 心脏病学
- 麻醉学
- 呼吸系统医学
背景情况:
- 患有冠状动脉疾病 (CAD) 的患者在胃肠内镜中对深度镇静的耐受性降低,导致心肌缺血和低血压的风险增加.
- 优化氧化和镇静对于这些高危患者的管理至关重要.
- 高流量鼻氧疗法 (HFNO) 在危险人群中有望预防低氧症.
研究的目的:
- 研究HFNO在加深镇静胃肠内镜治疗中增强心肌氧供应的疗效.
- 通过心脏循环效率 (CCE) 评估HFNO与标准氧气治疗 (SOT) 对心肌氧供需平衡的影响.
主要方法:
- 一个单中心的随机对照试验,涉及90名CAD患者接受深度镇静胃肠内镜检查.
- 患者将被随机分为1:1接受HFNO或SOT.
- 主要结果是镇静期间HFNO和SOT组之间的CCE差异,次要结果包括血液动力学稳定性和生化标志物.
主要成果:
- 主要结果是HFNO和SOT组之间的心脏周期效率 (CCE) 的差异.
- 二次结局包括低血压的发生率,低氧化,大脑性尿素,Troponin I和乳酸水平的变化,以及患者报告的结局.
- 将对MostCare的血液动力学参数进行分析.
结论:
- 这项研究旨在确定HFNO是否可以改善心肌氧供应并减少接受深度镇静内镜治疗的CAD患者的不良事件.
- 这些发现将为临床实践提供有关高风险心脏病患者在治疗过程中的氧化策略的信息.
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