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精神分裂症和双相情感障碍的药剂师干预:系统审查和元分析
Juliana Pimenta Netto1, Amanda Veiga Barbosa1, Brígida Dias Fernandes2
1School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Research in social & administrative pharmacy : RSAP
|August 22, 2025
概括
药剂师的干预有望改善精神分裂症和双相情感障碍患者的生活质量. 需要进一步的高质量研究来证实这些心理健康结果的发现.
科学领域:
- 药理学和临床药学
- 精神病学和心理健康研究
- 基于证据的医学
背景情况:
- 精神分裂症和双相情感障碍是导致残疾的重要原因.
- 药剂师对于治疗这些慢性精神疾病至关重要.
- 现有的文献缺乏对这些患者群体的药剂师干预措施的系统审查和元分析.
研究的目的:
- 对诊断为精神分裂症或BAD的患者改善健康结果的药剂师干预措施的有效性进行系统评估.
- 综合这些人群中药剂师领导的护理随机对照试验 (RCT) 的证据.
主要方法:
- 在PubMed,Cochrane Central,Embase和Google Scholar进行了全面的文献搜索,截至2024年3月.
- 在精神分裂症或BAD患者中评估药剂师干预的健康结果 (不包括药物经济学) 的RCT.
- 使用随机效应模型进行的元分析,并使用Rob 2工具评估偏差风险.
主要成果:
- 其中包括来自中等收入国家的7项RCT (2017-2024年),重点是精神分裂症 (4) 和BAD (3).
- 药剂师的干预措施,主要是健康教育,在两种条件下显著改善了生活质量 (WHOQOL-BREF).
- 临床和过程结果也显著改善,尽管所有研究都有很高的偏差风险,主要是在结果测量方面.
结论:
- 药剂师干预表明对精神分裂症和BAD患者的健康结果有潜在的积极影响.
- 目前的证据表明生活质量和其他结果有了显著的改善.
- 为了证实这些初步发现和指导临床实践,需要更多具有强大结果的RCT.
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