通过系统识别进行前列腺癌定位的三维剪切波粘性弹性估计
Xueting Li1, Florian Delberghe1, Simona Turco1
1Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Ultrasound in medicine & biology
|August 22, 2025
概括
通过剪波弹性图 (SWE) 使用体内粘度检测前列腺癌 (PCa) 是有前途的. 仅粘度就能达到与弹性相比的AUC,这表明它可以作为PCa定位的辅助生物标志物.
科学领域:
- 生物医学工程
- 医学成像
- 癌症学
背景情况:
- 剪波弹性成像 (SWE) 是一种先进的成像技术.
- 在体内估计组织粘度具有挑战性,但对疾病检测具有潜在价值.
研究的目的:
- 使用SWE估计体内前列腺粘度.
- 评估粘度以及弹性的前列腺癌 (PCa) 局部化潜力.
主要方法:
- 197名患者接受了三维SWE扫描.
- 使用系统识别 (SI) 来计算基于voxel的粘度和剪切波 (SW) 速度.
- 使用卷积神经网络和ROC曲线进行性能评估.
主要成果:
- 在恶性前列腺区域,弹性和粘度均显著较高.
- 来自SI的粘度达到PCa检测的AUC为0.68.
- 粘度的AUC与PCa局部化的弹性AUC相当.
结论:
- 这项研究报告了使用SWE的第一个基于体的前列腺粘度.
- 单独的粘度表现与PCa检测的弹性相比.
- 粘度可以作为前列腺癌局部化的辅助生物标志物.
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