纤维肌痛患者中的大麻与安慰剂:随机,双盲,安慰剂对照,并行组,单中心试验
Marianne Uggen Rasmussen1, Robin Christensen2, Eva Ejlersen Wæhrens3
1Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Annals of the rheumatic diseases
|August 22, 2025
概括
在一项随机试验中,大麻 (CBD) 与安慰剂相比没有有效地减轻纤维肌痛. 这项研究发现,每天服用50毫克CBD对纤维肌痛患者没有任何止痛效益.
科学领域:
- 治疗疼痛
- 药理学
- 临床试验
背景情况:
- 纤维肌痛是一种慢性疼痛疾病,
- 大麻 (CBD) 已被用于缓解疼痛,但对纤维肌痛的证据很少.
研究的目的:
- 在纤维肌痛患者中评估每天50毫克大麻 (CBD) 与安慰剂的疗效和安全性.
- 为了确定CBD在24周内减轻疼痛强度方面是否优于安慰剂.
主要方法:
- 一个单中心,双盲,随机,安慰剂对照试验涉及200名纤维肌痛患者.
- 参与者被随机分配到接受50毫克植物性CBD或安慰剂.
- 在24周使用修订的纤维肌痛影响问卷测量疼痛强度.
主要成果:
- 与CBD组相比,安慰剂组在24周后的疼痛强度下降幅度更大 (-1.1分).
- 疼痛减轻的差异优于安慰剂 (- 0. 7 分,P = . 0028).
- 在CBD和安慰剂组中,不良反应是轻微的,分布相似.
结论:
- 每天50毫克大麻 (CBD) 不被认为是有效的止痛补充剂.
- 该研究没有发现证据支持CBD用于纤维肌痛疼痛治疗.
更多相关视频
11:26Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients
Published on: July 14, 2018
17.4K
04:50Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
334
相关概念视频
01:11Blinding
2.6K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.6K
01:54The Placebo Effect
6.3K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.3K
02:07Blind Procedures
12.1K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
12.1K
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
366
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
366
01:09Peripherally and Centrally Acting Muscle Relaxants: A Comparison
3.7K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
3.7K