在非阻塞性和阻塞性缩性心肌病患者之间的口腔微生物组
Qianyi Qin1, Yuming Zhu2, Liu Yang3
1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Chinese medical journal
|August 22, 2025
概括
在非阻塞性缩性心肌病 (noHCM) 和阻塞性缩性心肌病 (oHCM) 患者中,口腔微生物组不同. 具体来说,没有HCM的患者表现出较高的 Porphyromonas gingivalis 丰度,这可能会影响临床区别.
科学领域:
- 心血管医学
- 微生物组研究
- 基因组学
背景情况:
- 口腔微生物组在缩性心肌病 (HCM) 中的作用在很大程度上是未知的.
- 非阻塞性HCM (noHCM) 和阻塞性HCM (oHCM) 之间的临床和微生物差异尚未被探索.
研究的目的:
- 调查和比较无HCM和oHCM患者的口腔微生物组特征.
- 识别与HCM亚型相关的潜在微生物生物标志物.
主要方法:
- 对18名无HCM和26名oHCM患者进行横截面研究.
- 临床,牙周和下斑块样本分析.
- 用于微生物组成和功能分析的基因组测序.
主要成果:
- 在口腔微生物组的整体多样性或组成上没有显著差异.
- 十种类型表现出显著的差异; Porphyromonas gingivalis 在 noHCM 中更为丰富.
- 功能分析显示,noHCM和oHCM组之间存在不同的代谢途径.
结论:
- 在noHCM中增加的 Porphyromonas gingivalis 可能导致临床变异.
- 在HCM亚型中,微生物功能转移表明宿主代谢发生变化.
- 口腔微生物组分析提供了对HCM病理生理学的见解.
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