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在北欧的BOLD研究中,全身炎症,肺功能和呼吸系统症状之间的关联
Lucia Cestelli1,2, Andre F S Amaral3, Bryndis Benediktsdottir4,5
1Department of Clinical Science, University of Bergen, PO Box 7804, Bergen, 5020, Norway. lucia.cestelli@uib.no.
通过白细胞计数测量的全身炎症与慢性气流阻塞和喘息有关. 这些关联因吸烟状况而异,影响呼吸系统健康.
科学领域:
- 肺部医学
- 免疫学
- 流行病学
背景情况:
- 系统性炎症在呼吸系统疾病发病过程中的作用已得到认可.
- 具体的炎症标志物,肺功能和呼吸系统症状之间的准确联系需要进一步阐明.
研究的目的:
- 研究系统性炎症标志物与呼吸系统健康结果之间的关联.
- 探索这些关联如何在不同的吸烟状态中变化.
主要方法:
- 在阻塞性肺病 (BOLD) 队列研究中分析了1,238名成年人的数据.
- 使用白细胞数量和亚群 (中性细胞,淋巴细胞,单细胞,乙细胞,基细胞,NLR) 来评估系统性炎症.
- 对人口和生活方式因素进行调整的回归模型.
主要成果:
- 大多数白细胞亚群,不包括淋巴细胞,与慢性气流阻塞 (CAO) 和喘息有关.
- 在从未吸烟的人群中,中性粒细胞的增加与肺体积的减少相关,而基基粒细胞的增加与CAO相关.
- 在前吸烟者中,中性细胞,单细胞和乙细胞与肺功能减弱,CAO和喘息有关.
- 在目前的吸烟者中,炎症标志物与咳有关.
结论:
- 在一般人群中,全身炎症与阻塞性和限制性呼吸功能障碍有关.
- 炎症标志物与呼吸系统健康之间的关系受吸烟状态的影响.
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