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Updated: Sep 10, 2025

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通过两个阶段的过渡,SARM1的激活促进了轴突退化

Wenbin Zhang1,2, Qinyi Zhou1,2, Jun Zhang1,2

  • 1Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.

Nature chemical biology
|August 22, 2025
PubMed
概括

尼古丁胺单核酸 (NMN) 通过形成纤维激活SARM1,一个导致轴突退化的蛋白质. 这一过程涉及ADP- 核糖结合物,揭示了受损轴突中SARM1激活的两步机制.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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