父亲对微生物群的操纵影响了后代的微生物殖民和发展
Kim-Sara Wagner1, Frédéric Salasc2,3, Silke-Mareike Marten2
1Marine Evolutionary Biology, Zoological Institute, Kiel University, 24118, Kiel, Germany. kwagner@zoologie.uni-kiel.de.
Scientific reports
|August 22, 2025
概括
管鱼的雄性怀孕可以分离母体和父体的微生物贡献. 父亲通过男性怀孕提供显著影响后代微生物组的发展和存活.
科学领域:
- 微生物学
- 进化生物学
- 生殖生物学
背景情况:
- 微生物通过垂直传播 (父母传播给后代) 和水平传播 (环境传播).
- 垂直传播对于宿主微生物的共存至关重要,但途径往往是母性和复杂的.
- 雄性怀孕提供了一个独特的模型来区分父系和母系的微生物供应.
研究的目的:
- 通过实验研究男性管鱼的垂直微生物群.
- 评估父亲的微生物供应对后代微生物组的发展和生存的影响.
主要方法:
- 男管鱼用抗生素治疗,然后用特定的细菌 (父,母,环境) 再殖民.
- 使用16S rRNA基因测序分析后代微生物组的组成.
- 对孕期和后代的存活率进行了监测.
主要成果:
- 父亲的抗生素和细菌"尖端"治疗改变了繁殖袋和后代的微生物组成.
- 父亲的"尖端"治疗减少了怀孕时间,增加了后代的存活率.
- 不同的垂直微生物传播途径塑造了后代的微生物组.
结论:
- 在男性怀孕期间,父亲的微生物供应是后代发育的重要因素.
- 了解不同的垂直微生物传播途径是全生物健康和疾病研究的关键.
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