调查社会获得的nocebo效应是否可以扩散到其他治疗方法
Cosette Saunders1, Winston Tan2, Kirsten Barnes3
1School of Psychology, A18, University of Sydney, Sydney, NSW, 2006, Australia. cosette.saunders@sydney.edu.au.
Scientific reports
|August 22, 2025
概括
在社会上获得的nocebo效应中,观察副作用会引起其他人的副作用,可以将其推广到不同的治疗方法中. 这项研究发现,虽然社交模式没有增强nocebo效应,但它确实增加了头痛等一般副作用.
科学领域:
- 心理学
- 神经科学
- 社会认知
背景情况:
- 观察其他人经历治疗副作用可以在个体中诱导类似的效果,即使是安慰剂治疗.
- 社会性副作用的现象及其对不同治疗方法的潜在泛化仍未得到充分研究.
研究的目的:
- 通过观察安慰剂治疗引发的社会获得副作用是否可以泛化为类似但不相同的治疗.
- 检查社会建模和口头建议对nocebo效应的影响.
主要方法:
- 120名健康志愿者被随机分为四组:相同治疗副作用的社会建模,不同治疗副作用的社会建模,只有口头建议和无治疗对照.
- 参与者接受了安慰剂认知增强剂.
- 报告的副作用的严重程度是主要的结局指标.
主要成果:
- 所有安慰剂组都表现出nocebo效应,报告症状严重程度增加.
- 社会建模并没有显著增强主要的nocebo效应.
- 社会建模显示对包括头痛和头在内的一般副作用具有添加效应,这些副作用在不同治疗方法中普遍存在.
结论:
- 社会诱导的nocebo效应可能不会始终发生,但当它们发生时,可能会超出相同治疗的范围.
- 在治疗过程中,社会性副作用的普遍性,特别是头痛和头,需要进一步研究.
- 广泛的治疗信息共享可能会导致nocebo效应的社会负担.
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