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Updated: May 8, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
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DNA 体 AptERA 2 向 Staphylococcus aureus 的 ERA,并限制了 GTP 的水解

Katherin Peñaranda1,2, Nicolle Pereira3, Orestis Savva4

  • 1Laboratory of Biomolecules, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), 15023, Lima, Peru. katherin.penaranda@upc.pe.

Scientific reports
|August 22, 2025
PubMed
概括

针对ERA蛋白的aptamers增强了对细菌核糖体组合的理解. 这项研究确定了与ERA结合的特定体.

关键词:
艾普塔梅尔时间表一个GTPase核糖体组合这里是SELEX

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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...