类风湿性关节炎患者的牙脱落与死亡率之间的关联
Andi Xu1, Chunhong Zhang1, Honghua Lv1
1Department of Immunology and Rheumatology, Lishui Central Hospital and Fifth Affiliated Hospital of Wenzhou Medical University, China.
British dental journal
|August 23, 2025
概括
在类风湿性关节炎 (RA) 患者中,牙损失与死亡率增加有关. 然而,十个或更多的牙缺失后,心血管死亡风险就会降低.
科学领域:
- 关节病学
- 心脏病学
- 牙公共卫生
背景情况:
- 类风湿性关节炎 (RA) 是一种与心血管疾病 (CVD) 风险增加相关的全身性自身免疫性疾病.
- 口腔健康,特别是牙损失,已被调查其与全身健康结果的关联.
- 在RA患者中,牙损失程度与死亡率之间的关系尚不完全理解.
研究的目的:
- 在风湿性关节炎 (RA) 患者中调查缺失牙数量与全因和心血管死亡率之间的关联.
主要方法:
- 针对18岁以上的RA患者使用了国家健康和营养检查调查 (1999-2004年和2011-2014年) 的数据.
- 包括详细的口腔检查来评估缺失的牙数量.
- 使用考克斯回归模型和受限立方线来分析与牙损失相关的死亡风险.
主要成果:
- 对1720名RA患者进行了随访,其中627人死亡 (191人死于心血管疾病).
- 每个额外的缺失牙与所有原因的死亡风险增加了2%.
- 与没有牙的患者相比,缺少15至28颗牙的患者的全因和心血管死亡风险显著增加.
- 有趣的是,在缺少10个以上牙的患者中,心血管死亡风险减少了14%的额外缺失牙.
结论:
- 在RA患者中,牙损失与全因死亡率的增加有关.
- 如果缺少的牙数量不到十个, 心血管死亡风险会增加.
- 当缺失的牙数量为十个或更多时, 观察到心血管死亡风险的矛盾降低.
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