与呼吸系统参数和肺部疾病相关的发生性心律失常:来自两个前性队列研究的证据
Yun-Jiu Cheng1, Li-Ping Qu2, Yi-Jian Liao3
1Department of Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. cheng831011@sina.com.
通过FEV1%和FVC%测量的肺功能下降与患心律失常的风险增加有关,包括心房动和心室心律失常. 这些发现突显了肺功能作为心律失常的潜在指标.
科学领域:
- 心脏病学
- 肺病学
- 流行病学
背景情况:
- 肺功能障碍越来越多地被认为是心血管疾病发展的一个因素.
- 肺功能与发生心律失常的风险之间的具体关系尚不清楚.
研究的目的:
- 调查呼吸系统参数和肺部疾病表型与心律失常的发生率之间的关联.
- 在不同的人群中评估这些联系.
主要方法:
- 在社区动脉样硬化风险 (ARIC) 和心血管健康研究 (CHS) 队列中分析了17684名成年人的数据.
- 前性队列研究设计,随访时间中位数为12.6年.
- 使用多变量调整的Cox比例危险模型来评估螺旋计测量 (FEV1%,FVC%) 和心律失常风险之间的关系,控制心血管风险因素.
主要成果:
- 预计1秒内强制呼气量 (FEV1%) 和强制生命能力 (FVC%) 的降低与各种心律失常的风险的分级增加有关.
- 最低FEV1%的四分位数显示出任何心律失常,心房动/跳动,心室失常,高度心室阻塞和早产心房/心室复合症的风险显著增加.
- 在从未吸烟者和两个群体中,相关性保持一致,阻塞性精神测量模式显示出最强的风险升高.
结论:
- 肺功能下降独立地与发生心律失常的风险增加有关,包括脑上腔,心室和导电系统疾病.
- 螺旋测量指数可以作为心律失常发展的新型独立预测指标.
- 这些关联与传统的心脏代谢风险因素不同,表明肺部健康在心血管结果中起着独特的作用.
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