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针对B7-H3和CSPG4的CAR-T细胞作为形甲状腺癌的强效因子

Giulia Cattaneo^1,2, Marco Ventin^1,2, Shahrzad Arya^1,2

¹Division of Gastrointestinal and Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Journal of experimental & clinical cancer research : CR

|August 23, 2025

概括

针对CSPG4和B7-H3的化学抗原受体 (CAR) T细胞治疗显示出对抗甲状腺癌 (ATC) 的希望. 这种免疫疗法在试验室和临床前模型中有效地消灭了ATC细胞,为这种侵袭性癌症提供了潜在的新疗法.

科学领域:

免疫学
癌症学
生物技术

背景情况:

甲状腺癌 (ATC) 是一种具有有限治疗选择和不良预后的恶性瘤.
化学抗原受体 (CAR) T 细胞治疗为ATC提供了潜在的治疗途径.
CSPG4和B7-H3在ATC上表达很高,在正常组织上表达很小,因此它们是尽量减少毒性的合适目标.

研究的目的:

研究针对CSPG4和B7-H3的CAR-T细胞在形甲状腺癌中的有效性.
评估CSPG4和B7-H3作为ATC免疫治疗的治疗点的潜力.

主要方法:

使用具有CD28共刺激域的第二代结构生成CSPG4特异性和B7-H3特异性CAR T细胞.
在体外对抗甲状腺癌细胞系的抗瘤活性进行了评估.
在ATC的异种移植小鼠模型中评估了体内疗效.

主要成果:

甲状腺癌细胞在体外被针对CSPG4和针对B7- H3的CAR T细胞特异地识别并有效地根除.
在临床前的ATC模型中,用CSPG4 CAR T细胞或B7- H3 CAR T细胞治疗导致显著的瘤控制或完全根除.
这两种CAR T细胞在体内都表现出强烈的抗瘤活性.

结论:

CSPG4和B7-H3已被验证为甲状腺癌免疫治疗的有价值的向抗原.
针对CSPG4和B7-H3的CAR T细胞免疫疗法为形甲状腺癌提供了一个有前途的治疗策略.
这些发现支持对耐药或复发性疾病的ATC患者进行CSPG4和B7- H3CAR T细胞治疗的临床探索.

关键词:

甲状腺癌的发生 B7-H3 其他汽车T 在CSPG4 免疫疗法

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