女性生殖因子与关节炎风险的关联:基于人口的横截面研究
Jiajia Wang1, Yiting Ge2, Jingbo Xu3
1Department of Rheumatology, Shaoxing People's Hospital (The First Affiliated Hospital, Shaoxing University), No. 568 Zhong Xing Road, Shaoxing, Zhejiang, 312000, China.
Reproductive health
|August 23, 2025
概括
早期或晚期生育女性患关节炎的风险更高. 在关节炎预防和查策略中, 生殖因素如出生年龄至关重要.
科学领域:
- 生殖健康
- 流行病学
- 关节病学
背景情况:
- 女性生殖因子越来越多地被认为对慢性病发病率的潜在影响.
- 了解生殖史与关节炎之间的关系可以为公共卫生策略提供信息.
研究的目的:
- 研究女性生殖关键因素与关节炎患病率之间的联系.
- 具体地检查与关节炎相关的第一个出生年龄 (AFB),最后一个出生年龄 (ALB),怀孕数量和活产.
主要方法:
- 从1999年至2018年国家健康和营养检查调查 (NHANES) 的横截面数据分析.
- 使用加权多变量逻辑回归,限制立方线 (RCS) 模型和子组分析.
- 调整了潜在的混因素,以确保可靠的发现.
主要成果:
- 在AFB和总体关节炎患病率,骨关节炎 (OA),类风湿性关节炎 (RA) 和其他类型的关节炎的怀孕之间观察到U形相关性.
- 在OA和RA的怀孕中发现了J形关联.
- 在ALB和患有关节炎的活产儿之间发现了负相关性,在ALB和OA/其他关节炎以及患有其他关节炎的怀孕中发现了特定的线性负相关性.
结论:
- 较年轻或较晚的出生年龄 (AFB) 与晚年患关节炎 (OA和RA) 的几率增加有关.
- 包括AFB和ALB在内的生殖因素是关节炎查和预防工作的重要考虑因素.
- 怀孕和活产的数量也显示出与关节炎患病率的复杂,有时是相反的关系.
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