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两个样本的孟德尔随机化研究检查缺血性中风和阻塞性睡眠呼吸暂停之间的因果关系

Qing Yu¹, Wei Wei², Ying Yuan¹

¹Department of Acupuncture and Neurology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.

Brain and behavior

|August 23, 2025

概括

心血管栓塞性中风 (CES) 增加了阻塞性睡眠呼吸暂停 (OSA) 的风险,但其他类型的缺血性中风与OSA没有因果关系. 这种基因分析显示CES和OSA之间存在正相关性.

科学领域:

神经学
遗传学
睡眠医学

背景情况:

观察性研究表明缺血性中风和阻塞性睡眠呼吸暂停之间存在联系.
IS亚型与OSA之间的确切因果关系尚不清楚.
孟德尔随机化 (MR) 可以使用遗传变异来调查潜在的因果关系.

研究的目的:

评估IS亚型 (大动脉中风[LAS],心血管中风[CES],小血管中风[SVS]) 和OSA之间的因果关系.
使用孟德尔的随机化方法来评估这些关系.
澄清中风和睡眠呼吸暂停之间的病因关系.

主要方法:

使用欧洲人口数据进行了双样本孟德尔随机分析.
被调查的IS (n=440,328),LAS (n=410,484),CES (n=413,304),SVS (n=198,048) 和OSA (n=451,618) 的人数.
主要采用逆方差加权 (IVW) 方法;灵敏度分析包括离开一次,MR-Egger和MR-PRESSO测试.

主要成果:

基因预测的CES与增加的OSA风险显著相关 (IVW:OR=1.07,p=0.004).
在IS,LAS或SVS和OSA发病率之间没有发现直接的因果关系.
敏感性分析证实没有显著的异质性或偏差.

结论:

心血管栓塞性中风 (CES) 被认为是阻塞性睡眠呼吸暂停 (OSA) 的危险因素.
其他IS亚型 (LAS,SVS) 与OSA之间没有直接的因果关系.
这表明CES和OSA之间存在积极的遗传相关性.

关键词:

孟德尔随机化心血管血管中风缺血性中风阻塞性睡眠呼吸暂停

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