超重中国人的白质变化的认知影响:NODDI和DTI研究
Shaofan Jiang1, Yingzhe Cheng2,3,4,5,6, Rifeng Jiang1
1Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.
Brain and behavior
|August 23, 2025
概括
超重个体表现出与认知功能和血生物标志物相关的白质微观结构变化. 这些超重状态的WM异常可能会影响认知能力.
科学领域:
- 神经成像
- 神经学
- 代谢健康
背景情况:
- 对超重个体的白质 (WM) 微观结构变化进行的研究有限.
- 了解这些变化对于OW人群的认知健康评估至关重要.
研究的目的:
- 研究标准重量 (SW) 和OW参与者之间的WM微观结构差异.
- 探索OW中的WM完整性,认知领域和等离子体生物标志物之间的关系.
主要方法:
- 使用神经元定向分散和密度成像 (NODDI) 和扩散张力成像 (DTI) 来评估WM完整性.
- 在SW和OW集团之间比较NODDI和DTI指标的兴趣区域 (ROI) 值.
- 与认知评估和等离子体生物标志物相关联的WM微结构指标.
主要成果:
- 在广泛的WM区域 (p < 0. 05) 观察到分数异构 (FA) 和方向分散指数 (ODI) 的显著差异.
- 在未切割 (UF) 中的NODDI参数与认知领域有显著的相关性.
- 其他WM微观结构异常与认知功能和血生物标志物有关.
结论:
- 微观结构异常是OW状态的特征.
- 这些变化显然与认知功能和相关的血生物标志物有关.
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