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循环粘膜相关的不变T细胞与人类急性缺血性中风有关,并预测不良结果

Tadashi Ozawa¹, Asako Chiba², Hiroko Hayakawa³

¹Division of Neurology, Department of Medicine Jichi Medical University School of Medicine Tochigi Japan.

Journal of the American Heart Association

|August 23, 2025

概括

急性缺血性中风与粘膜相关的不变T细胞 (MAIT) 的显著早期减少有关. 较低的MAIT细胞数与中风严重程度相关,并预测患者的治疗结果不佳.

科学领域:

免疫学
神经学
细胞生物学

背景情况:

粘膜相关的不变T细胞 (MAIT) 在急性缺血性中风的小鼠模型中涉及.
这项研究研究了急性缺血性中风患者循环MAIT细胞的行为和功能.

研究的目的:

在急性缺血性中风患者中阐明MAIT细胞的动态.
在急性缺血性中风患者中,确定MAIT细胞群,它们的激活状态,细胞因子产生和临床结果之间的相关性.

主要方法:

患有急性缺血性中风的患者分为重症 (NIHSS ≥10) 和轻症 (NIHSS < 10) 组,对照组为年龄和性别匹配的门诊患者.
在中风后3,10和17天使用流细胞计分析循环MAIT细胞,它们的激活标记 (CD69+) 和细胞因子 (IFN-γ+,IL-17+) 以及其他T细胞子集.
使用多变量分析评估了MAIT细胞动态与3个月临床结果之间的关系.

主要成果:

与轻度中风和对照组相比,在第3天观察到MAIT细胞的比例显著降低 (0. 09% vs 0. 33% vs 0. 38%,P < 0. 001),在第17天逐渐恢复.
严重中风患者的MAIT细胞表现出增加的CD69表达和更高的IL-17产生.
在第3天,MAIT细胞群的最低四分位数与3个月不良结果的可能性显著增加 (OR,21. 64;P = 0. 027).

结论:

早期MAIT细胞数量的减少,加上激活和促炎细胞因子 (IL-17) 的产生,与急性缺血性中风的严重程度有关.
这些发现表明MAIT细胞在急性脑梗塞的病理生理学和不良临床结果的发展中起着关键作用.

关键词:

玛特拉T细胞不变的自然杀手T细胞缺血性中风粘膜相关的不变T细胞糟糕的结果

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