CLEC18A与硫酸糖氨基相互作用,控制清细胞癌的进展.
在PubMed上查看摘要
概括
此摘要是机器生成的。在清细胞细胞癌 (ccRCC) 的进展中,C型莱克域家族18 (CLEC18) 基因,特别是CLEC18A,至关重要. 在ccRCC瘤中,高CLEC18表达与患者更好的生存率和小鼠瘤增长的抑制有关.
科学领域
- 分子生物学
- 癌症学
- 免疫学
背景情况
- C型莱克是参与各种生物过程的多功能蛋白质,包括癌症.
- 许多C型莱克在癌症中的作用尚不清楚,需要进一步研究.
- 甲状腺体中C型莱克域家族18 (CLEC18) 存在,在人类中经常发生重复.
研究的目的
- 研究CLEC18家族,特别是CLEC18A在清细胞癌 (ccRCC) 进展中的作用.
- 确定CLEC18A连接体,并了解其在和大脑中的功能.
- 在ccRCC患者中确定CLEC18家族基因表达的临床意义.
主要方法
- 对CLEC18家族基因保存和重复的生物信息分析.
- 在正常的和脑组织中分析CLEC18A表达模式.
- 通过生物化学测试识别CLEC18A配体.
- 在ccRCC中对CLEC18家族基因表达与患者生存数据的相关性分析.
- 在Clec18a删除的小鼠模型中评估瘤生长.
主要成果
- CLEC18A在附近管和大脑中间管中表达.
- 硫酸糖氨基酸被确定为主要的CLEC18A配体.
- 在ccRCC瘤中,CLEC18家族基因的高表达与患者生存率的改善有关.
- 在小鼠模型中,Clec18a的丧失导致了ccRCC瘤的加速生长.
结论
- CLEC18A是ccRCC瘤生长的新型和关键调节剂.
- 需要进一步研究CLEC18A独特的连接物特异性 (硫酸糖氨基酸).
- 调节CLEC18家族基因表达可能为ccRCC提供治疗策略.
相关概念视频
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

