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在阻塞性睡眠呼吸暂停综合征中评估视网膜输液和血管密度

Xuan Cai¹, Xue Wu¹, Hao Chen¹

¹Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of sleep research

|August 23, 2025

概括

阻塞性睡眠呼吸暂停综合征 (OSAS) 与眼睛疾病有关. 在中度至重度的OSAS患者中,OTA显示了视网膜血管密度和输液的显著变化.

科学领域:

眼科眼科
睡眠医学
医学成像

背景情况:

阻塞性睡眠呼吸暂停综合征 (OSAS) 与各种眼部疾病有关.
之前的研究表明OSAS与视神经病变,青光眼和视网膜血管疾病之间存在联系.

研究的目的:

使用扫描来源的OCTA评估视网膜血管密度和OSAS患者的输液变化.
这些血管变化与睡眠呼吸暂停的严重程度相关联.

主要方法:

八十名患有OSAS的参与者接受了多睡眠扫描和扫描源OCTA (12x12mm扫描).
参与者被分为轻度,中度和严重的OSAS组.
在不同视网膜层和细分区域分析了血管密度和 perfusion.

主要成果:

在视网膜,内视网膜,胆膜,神经纤维,表面血管 (SVP) 和中间毛细血管 (ICP) 中发现了显著的输液区别.
在视网膜内部,神经纤维和ICP中,血管密度有显著差异.
呼吸暂停指数得分与视网膜,SVP和ICP的输液,以及神经纤维层,SVP和ICP的血管密度相关.

结论:

中度至严重的OSAS与视网膜血管密度和 perfusion 的显著变化有关.
扫描来源的OCTA是一种有前途的非侵入性工具,用于评估与OSAS相关的眼睛血管变化.

关键词:

微循环阻塞性睡眠呼吸暂停综合征光学连贯断层扫描血管学视网膜循环视网膜血管密度

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