Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Causality in Epidemiology01:21

Causality in Epidemiology

822
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
822
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

155
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
155
What are Estimates?01:06

What are Estimates?

5.4K
It isn't easy to measure a parameter such as the mean height or the mean weight of a population. So, we draw samples from the population and calculate the mean height or mean weight of the individuals in the sample. This sample data acts as a representative measure of the population parameter. These sample statistics are known as estimates. 
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
5.4K
Null and Alternative Hypotheses01:16

Null and Alternative Hypotheses

10.0K
The actual hypothesis testing begins by considering two hypotheses. They are termed  the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As  a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
10.0K
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

635
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
635
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data01:16

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

208
Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
208

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A multi-site laboratory evaluation of the MEDSCAN application for automated POC-CCA interpretation.

Frontiers in parasitology·2026
Same author

Phase 3 PERSPECTIVE study: Ibrutinib with rituximab for initial treatment of patients with follicular lymphoma.

HemaSphere·2026
Same author

CD8 T lymphocytes deploy embryonic cell cycle control mechanisms for rapid cell proliferation.

EMBO reports·2026
Same author

Staff Perspectives on Non-Routine Compression Therapy for Inpatients With Venous Leg Ulcers: A Qualitative Study.

International wound journal·2026
Same author

Defining disease stability in COPD: Evidence from Phase 3 clinical trials.

American journal of respiratory and critical care medicine·2026
Same author

Central and Peripheral Alterations of Retinal and Choroidal Vasculature in Multiple Sclerosis: Insights from Multimodal Imaging.

Ophthalmology science·2026
Same journal

Impact of Information Leakage in Platform Trials With Survival Endpoints on Type I Error Control.

Pharmaceutical statistics·2026
Same journal

Harmonic Fowlkes-Mallows Index for Medical Diagnostics Tests and Optimal Cut-Off Point Selection of Binary Diseases.

Pharmaceutical statistics·2026
Same journal

Early Phase Dose-Finding Designs for CAR-T Cell Therapies.

Pharmaceutical statistics·2026
Same journal

Optimizing Randomization Ratios in Clinical Trials With Survival Endpoints.

Pharmaceutical statistics·2026
Same journal

CUI-MET: A Clinical Utility Index Based Analysis and Decision Framework for Dose Optimization in Multiple-Dose, Multiple-Outcome Randomized Trials.

Pharmaceutical statistics·2026
Same journal

Will the Pharmaceutical Industry Need Statisticians in an AI World?

Pharmaceutical statistics·2026
查看所有相关文章

相关实验视频

Updated: Sep 10, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K

估计框架和因果推理:互补而非竞争的范式

Thomas Drury1, Jonathan W Bartlett2, David Wright3

  • 1GSK, London, UK.

Pharmaceutical statistics
|August 23, 2025
PubMed
概括
此摘要是机器生成的。

ICH E9 (R1) 估计框架和因果推断为在临床试验中定义治疗效果提供了补充方法. 了解这两种方法可以提高试验设计,分析和解释的清晰度.

更多相关视频

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View
05:26

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View

Published on: January 7, 2019

6.8K
Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal
06:45

Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal

Published on: April 18, 2017

6.3K

相关实验视频

Last Updated: Sep 10, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K
Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View
05:26

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View

Published on: January 7, 2019

6.8K
Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal
06:45

Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal

Published on: April 18, 2017

6.3K

科学领域:

  • 生物统计学
  • 临床试验设计
  • 流行病学

背景情况:

  • 国际协调委员会E9 (R1) 准则为临床试验中精确的治疗效果规范引入了一个估计框架.
  • ICH E9 (R1) 估计框架与因果推理之间的关系仍然不清楚,尽管两者都定义了估计.

研究的目的:

  • 将ICH E9 (R1) 估计框架与因果推断进行比较和对比.
  • 为了说明这两个框架如何定义基于人群的治疗效应.
  • 在临床试验方法中强调这两种模式的互补性.

主要方法:

  • 使用示例来比较ICH E9 (R1) 估计框架和因果推断.
  • 分析了定义估值的相似之处和差异.
  • 讨论了每个框架的可访问性和数学精度.

主要成果:

  • ICH E9 (R1) 和因果推理都可以定义基于人群的治疗效应.
  • ICH E9 (R1) 框架提供了一个结构化,可访问的沟通方法.
  • 因果推理通过因果图等工具提供了数学精度和明确的假设表达.

结论:

  • ICH E9 (R1) 估计框架和因果推断是互补的,而不是相互竞争的.
  • 整合这两种方法可以提高临床试验沟通的清晰度和稳定性.
  • 鉴于这两种框架的概念,可以加强临床试验的设计,分析和解释.