静坐行为和其预测COPD患者死亡率的截止点:一项12年的随访研究
Lais Santin1, Humberto Silva1, Thais Moçatto Tofoli1
1Laboratory of Research in Respiratory Physiotherapy (LFIP), Department of Physiotherapy, Universidade Estadual de Londrina, Londrina, Brazil.
每天静坐时间超过8. 5小时与慢性阻塞性肺病 (COPD) 患者的死亡风险增加有关. 这一发现突显了监测久坐行为对于更好的COPD治疗和预后的重要性.
科学领域:
- 肺部医学
- 老年学
- 流行病学
背景情况:
- 慢性阻塞性肺部疾病 (COPD) 的个体普遍存在久坐不动的行为.
- 在COPD患者中,静坐时间与死亡风险之间的关联需要进一步研究.
- 确定静坐行为的具体门对于风险分层至关重要.
研究的目的:
- 评估三种不同静坐行为对稳定的COPD患者全因死亡率的预测值.
- 为了比较静坐时间 (ST) >8.5小时/天,ST>70%的清醒时间,以及<4300步/天的死亡预测值.
- 在COPD治疗中建立临床相关的值.
主要方法:
- 分析了92名稳定的COPD患者的基线数据,这些患者接受了肺部康复治疗.
- 考克斯多变量回归模型的应用,以评估12年随访期间的死亡预测因素.
- 三个预定义的静坐行为截止值的比较:ST>8.5小时/天,ST>70%的清醒时间,<4300步/天.
主要成果:
- 每天超过8.5小时的静坐时间 (ST>8.5小时/天) 被确定为所有原因死亡率的独立预测因素.
- 每天ST> 8. 5小时的患者死亡风险增加了23% (HR为1. 23,95% CI为1. 021-1. 589,P=0. 02).
- 其他两种被评估的静坐行为与死亡率没有显著的关联.
结论:
- 每天静坐时间超过8.5小时是COPD患者死亡风险增加的重要指标.
- 监测和减少长时间的久坐行为可能是改善COPD患者生存的关键干预策略.
- ST>8.5小时/天作为一种有价值的标志物,用于识别高风险的COPD患者,以便进行更密切的跟踪和有针对性的干预.
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