听力分析仪对爆炸波引起的氧化应激的影响
Olga Rzhevska1, Vasyl Troian2, Irina Sinaiko2
1V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE.
概括
轻度爆炸性创伤性脑损伤 (METBI) 与声波创伤增加了氧化应激标志物,与神经感官听力损失 (SHL) 相对应. 抗氧化系统的缺陷加剧了这些影响.
科学领域:
- 神经科学
- 眼科 眼科
- 听力学
背景情况:
- 轻度爆炸性创伤性脑损伤 (METBI) 可能导致复杂的听力缺陷.
- 声波创伤是爆炸后的严重并发症.
- 氧化应激 (OS) 在TBI病理生理学中起作用.
研究的目的:
- 在METBI患者中量化创伤后氧化应激 (OS).
- 研究OS强度与神经感官听力损失 (SHL) 发生之间的关联.
主要方法:
- 研究了43名METBI患者的队列.
- 血液样本分析了OS标记物 (甲基,碳氧) 和抗氧化系统成分 (减少的谷,总).
- 还测量了氧化的含量.
主要成果:
- METBI显著增加了OS标记物:阿尔德海德基 (+53. 54%) 和基基基 (+50. 51%).
- 抗氧化能力下降:减少了谷氨 (-47. 4%) 和总醇 (-61. 7%),减少了氧化 (-54. 22%).
- 在SHL和增加的OS标志物 (APH,CPH) 之间发现了直接的相关性,以及与减少的谷氨缺乏的反相关性.
结论:
- 抗氧化剂保护的失衡有助于METBI后的微循环障碍.
- 这些发现突显了OS对内耳微循环的影响,并提出了减轻听力损失的治疗目标.
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