提高流感疫苗接种率:干预策略的系统审查和元分析
YuNing Wang1,2, YaZhen Zhang1,2, JiaYu Wang3
1Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Expert review of vaccines
|August 23, 2025
概括
全球流感疫苗接种率低于最佳水平. 这一元分析显示,干预措施显著增加了吸收率,针对特定高风险群体 (如老年人和儿童) 的定制策略是最有效的.
科学领域:
- 公共卫生
- 流行病学
- 疫苗学
背景情况:
- 全球流感疫苗接种率仍然低于最佳水平,特别是在高风险人群中.
- 提高疫苗接种率的努力对公共健康至关重要.
- 需要有针对性的干预措施来解决疫苗接种范围的差异.
研究的目的:
- 综合评估各种干预措施对流感疫苗接种的有效性.
- 确定哪些干预策略对不同的人口群体最有效.
- 为加强全球流感免疫接种提供基于证据的建议.
主要方法:
- 进行了系统的文献搜索,直到2023年4月.
- 包括对流感疫苗接种的干预有效性的实验研究.
- 使用随机效应的元分析,将风险比率 (RR) 与95%的置信区间 (CI) 结合起来.
主要成果:
- 总共分析了180项涉及2,390,119名参与者的研究.
- 干预措施显著增加了疫苗接种率,综合RR为1. 26 (95% CI,1. 21至1. 32).
- 提供者为基础的干预措施对医疗保健工作者有效,受益者为基础的干预措施对孕妇有效,多目标策略对老年人和儿童有效.
结论:
- 干预措施有效地提高了流感疫苗接种率.
- 为了优化特定人群的疫苗接种量身定制的策略至关重要.
- 这些发现为加强全球免疫工作的公共卫生策略提供了信息.
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