一般人口与癌症幸存者之间的小,低风险甲状腺癌健康状况评估的差异:横截面分析
Kendyl Carlisle1, Rebecca Kowalski1, Aprill N Park2
1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
概括
一般人群报告的甲状腺小瘤 (PTMC) 的健康效益低于甲状腺癌幸存者. 这些发现对于PTMC治疗决策中的比较有效性研究至关重要.
科学领域:
- 癌症学
- 健康经济学
- 患者报告的结果
背景情况:
- 乳头甲状腺小癌 (PTMC) 是一种低风险的甲状腺癌.
- 对于PTMC来说,越来越多地使用主动监测和射频剥离等不那么侵袭性治疗方法.
- 医疗公用事业对于共享决策和比较有效性模型至关重要,但需要明确的人口来源.
研究的目的:
- 将一般人口志愿者 (GenPop) 和甲状腺癌幸存者 (TCSurv) 之间的PTMC健康状况实用性估计进行比较.
- 为PTMC管理提供比较有效性研究和共享决策信息.
主要方法:
- 一个时间权衡任务被用来获得10个PTMC健康状态的健康实用程序.
- 参与者包括70名GenPop志愿者和72名甲状腺癌幸存者 (TCSurv).
- 进行单变量和多变量线性回归分析,对共变量进行调整,并对治疗并发症进行子组分析.
主要成果:
- 在所有10个PTMC健康状态中,GenPop报告的健康效益明显低于TCsurv.
- 在多变量分析中,GenPop和TCSurv之间的效用差异具有统计学意义 (p=0. 01).
- 与没有并发症的情景相比,PTMC情景的健康效益较低.
结论:
- 与甲状腺癌幸存者相比,一般人群志愿者报告PTMC健康状况的健康效益较低.
- 卫生经济学家和医疗保健提供科学家在PTMC的比较有效性研究中必须考虑这些差异.
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