精神分裂症的外周氧化压力标志物:阿尔及利亚患者的红细胞氨酸过氧化酶,血甲基和微量元素比率的洞察
Latefa Saidane1, Nouria Dennouni Medjati2, Yahia Harek3
1Analytical Chemistry and Electrochemistry Laboratory, Department of Biology, University of Abou Bekr Belkaid, 13000, Tlemcen, Algeria. saidanelatefa@gmail.com.
在精神分裂症患者中,氧化压力标志物如甲酸 (MDA) 升高,抗氧化酶甲酸过氧化酶 (GPX1) 活性降低. 微量元素不平衡,特别是铜/比,与精神分裂症风险有关.
科学领域:
- 神经科学
- 生物化学
- 临床医学
背景情况:
- 精神分裂症 (SCZ) 病理生理包括氧化应激 (OS),氧化过程和抗氧化防御之间的不平衡.
- 微量元素对神经生理功能和抗氧化能力至关重要,它们的失调可能会影响SCZ.
- 在SCZ中寻求中心OS的外围生物标志物来帮助诊断和管理.
研究的目的:
- 评估阿尔及利亚SCZ患者的血甲基 (MDA) 水平和红细胞谷氨酸过氧化酶 (GPX1) 活性.
- 测量血中的铜 (Cu), (Zn) 和 (Se) 度及其比率 (Cu/Zn,Cu/Se,Zn/Se).
- 评估这些参数作为SCZ中中央OS的潜在外围生物标志物.
主要方法:
- 使用光谱测量方法测量了血MDA和红细胞GPX1活性.
- 使用极光分析仪确定Cu,Zn和Se的等离子度.
- 用物流回归分析来确定与SCZ风险相关的因素.
主要成果:
- 与对照组相比,SCZ患者的血MDA水平较高,红细胞GPX1活性较低.
- 在SCZ患者中,血Cu,Zn和Se水平降低,Cu/ Zn/ Se比率较高.
- 确定Cu/ Se比率是与SCZ风险相关的重要因素 (OR = 1.535, p = 0.029).
结论:
- 在阿尔及利亚SCZ患者中,MDA升高,GPX1活性降低和微量元素的变化与OS有关.
- 微量元素不平衡,特别是Cu/Se比率,可能在SCZ病变发生过程中起作用.
- /比可以作为精神分裂症的外围生物标志物.
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