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Updated: Sep 10, 2025

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五十年来卡因酸受体研究的演变:趋势,热点和新兴前沿
Yunsheng Liu1,2, Rongde Zhong2, Yao-Xuan Li1
1Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Naunyn-Schmiedeberg's archives of pharmacology
|August 23, 2025
概括
这份文献分析绘制了五十年的卡因酸受体 (KAR) 研究,揭示了关键趋势和挑战. 未来的方向集中在子单位特定的药物和神经疾病的临床转化.
科学领域:
- 神经科学
- 药理学
- 图书统计学
背景情况:
- 凯纳酸受体 (KAR) 是关键的离子转移性谷氨酸受体,参与像突触可塑性这样的大脑功能.
- KARs的失调与神经和精神疾病,特别是有关.
研究的目的:
- 对1975年至2024年间的卡因酸受体 (KAR) 研究进行全面的文献分析.
- 确定KAR研究中的趋势,热点和新兴前沿.
- 提供全球贡献和转化潜力的概述,以指导未来的研究.
主要方法:
- 使用CiteSpace,VOSviewer和Bibliometrix对PubMed,Web of Science和Scopus的11,671个出版物的科学测量分析.
- 分析出版趋势,国家/机构贡献,期刊影响,作者生产力和关键词演变.
- 专题聚类和引用爆发分析以确定研究热点和时间转移.
主要成果:
- 由于分子克隆和分布研究,KAR研究在21世纪初达到顶峰,最近得到了稳定.
- 美国在生产力和影响力方面处于领先地位;
- 确定了研究阶段:分子特征 (1995-2005),功能/疾病研究 (2005-2015) 和先进技术 (2015-2024).
结论:
- 对于KAR调节剂的临床转化和理解它们在精神疾病中的作用仍然存在重大挑战.
- 未来的研究应优先考虑特定子单位的药物设计,跨学科的创新和全球合作.
- 这份图书统计路线图强调了KAR研究中的动态演变,协作模式和未满足的翻译需求.
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