相关实验视频

Updated: Sep 10, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

lncRNA MGP202在调节B细胞动态中的作用及其性结肠炎的影响

Runing Zhou¹, Xiaoyin Bai¹, Dongdong Zhang²

¹Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing, China.

Inflammatory bowel diseases

|August 23, 2025

概括

长非编码RNAMGP202在性结肠炎 (UC) 中受到上调,并通过化miR-5590-3p和影响IL-33影响B细胞增殖. 这表明MGP202是UC的潜在治疗点.

科学领域:

分子生物学
免疫学
胃肠病学

背景情况:

性结肠炎 (UC) 与长非编码RNA (lncRNA) 表达的改变有关.
在UC患者中,lncRNA MGP202的调高表明其在疾病发病过程中的潜在作用.
了解MGP202在B细胞动态中的功能对于UC诊断和治疗至关重要.

研究的目的:

研究MGP202在性结肠炎中的表达和功能.
阐明MGP202影响B细胞增殖和IL-33表达的机制.
评估MGP202作为UC的潜在诊断和治疗点.

主要方法:

检查了UC患者和健康对照者的结肠样本中的MGP202表达.
在Raji B细胞中进行了MGP202的淘汰和过度表达研究.
研究了MGP202与hsa- miR-5590-3p之间的相互作用及其对IL-33的影响.

主要成果:

在UC患者中,MGP202表达显著升高.
MGP202抑制了B细胞增殖,而过度表达则增强了它.
MGP202海绵hsa- miR-5590-3p,调节IL-33表达,在UC结肠粘膜中增加.

结论:

在UC中MGP202的上调调节通过海绵化hsa-miR-5590-3p和调节IL-33调节B细胞的增殖.
MGP202是UC的潜在诊断和治疗点,特别是在B细胞失调方面.
需要进一步研究MGP202在UC治疗中的临床适用性.

更多相关视频

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...