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Updated: May 11, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

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骨肉瘤的三维临床前模型:进展和转化前景

Aurora Puce1, Virginia Ferraresi2, Roberto Biagini3

  • 1Cellular Network and Molecular Therapeutic Target Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 23, 2025
PubMed
概括

三维 (3D) 培养模型如球体和有机体为研究骨髓瘤 (OS) 和测试新药提供了卓越的平台. 这些先进的模型更好地模仿瘤的微环境, 克服了旧方法的局限性, 以改善治疗发展.

关键词:
三维培养模型细胞外矩阵 (ECM) 动力学骨髓瘤精确的瘤模型瘤微环境 (TME)

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Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
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Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
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Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
Three-Compartment Open Model01:06

Three-Compartment Open Model

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