相关实验视频

Updated: Sep 10, 2025

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

基于拉曼成像和深度学习的血管改造的检测

Wenqian Jiang¹, Yixuan Su², Madi Guo¹

¹State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China; State Key Laboratory -Province Key Laboratories of Biomedicine-Pharmaceutics of China, and Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin 150081, China; Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|August 23, 2025

概括

通过分析组织部件, 拉曼成像能够准确地检测动脉衰老. 这种方法揭示了与原蛋白相关的代谢变化,为慢性疾病提供了新的治疗点.

科学领域:

生物医学工程
分子生物学
病理学

背景情况:

血管衰老有助于慢性疾病,需要早期检测方法.
目前用于动脉衰老的染色技术缺乏精度,并分析有限的成分.

研究的目的:

开发和验证拉曼成像技术,用于同时分析多个血管组织组件.
使用先进的分析算法区分年轻和老的大动脉组织.
识别与动脉衰老相关的代谢变化.

主要方法:

鼠标大动脉部分的高质量拉曼成像.
同时分析弹性纤维,I和III类型的原,细胞核和VSMC细胞质.
多变量曲线分辨率-交替最小平方 (MCR-ALS) 和数据分析的深度学习.

主要成果:

高精度的年轻和老的大动脉组织的成功分化 (AUC=0.986).
详细地绘制了五个主要组织成分的含量和分布变化.
鉴定与老化动脉中的原合成和后修饰相关的代谢变化.

结论:

拉曼成像结合MCR-ALS和深度学习是检测血管衰老的强大工具.
这项研究提供了对动脉衰老所影响的代谢途径的见解,表明了潜在的治疗点.
这种方法为监测血管衰老过程提供了精确和全面的方法.

关键词:

动脉衰老原纤维深度学习其他类型氨酸拉曼成像血管改造

更多相关视频

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

相关概念视频

Imaging Studies VII: Vascular Imaging

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...