在前列腺癌患者中,CT衍生的心肌细胞外体量预测主要的心血管不良事件
在PubMed上查看摘要
概括
此摘要是机器生成的。胸部CT扫描可以监测ADT的前列腺癌患者的心脏损伤. 在这些患者中,心肌心电量升高预测主要心血管不良事件 (MACE).
科学领域
- 心脏病学
- 癌症学
- 放射学
背景情况
- 接受雄激素剥夺疗法 (ADT) 的前列腺癌 (PCa) 患者面临心脏毒性和主要心血管不良事件 (MACE) 的风险增加.
- 通过胸部对比度增强CT (CECT) 测量的心肌细胞外体积 (ECV) 在检测心脏毒性和预测MACE的有效性尚不清楚.
研究的目的
- 评估胸部CECT衍生的心肌心电图在确定心脏毒性的有效性.
- 在接受ADT的PCa患者中评估心肌心脏ECV和MACE之间的关联.
主要方法
- 对使用ADT的PCa患者的回顾性分析 (2014年12月 - 2020年3月).
- 在开始ADT之前和3,6,9,12个月后,使用胸部CECT测量肌肉心脏ECV.
- 统计分析包括Student的t测试和Cox的比例危险建模,以比较MACE组之间的ECV并评估MACE风险.
主要成果
- 包括180名患者,其中44名患有MACE.
- 肌肉心脏ECV从基线显著增加3个月的ADT,在12个月达到峰值.
- 在ADT后3个月,6个月和9个月,心肌心电率较高与MACE风险增加有关 (aHR分别为2. 695,3. 670,4. 450).
结论
- 从胸部CECT获得的肌肉心脏ECV有效监测PCa患者的心脏毒性.
- 胸部CECT衍生的心肌心电量是MACE的重要预测指标.
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