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Agata Sularz¹, Alejandra Chavez-Ponce¹, Ghasaq Saleh¹

¹Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

|August 23, 2025

概括

适度镇静 (MS) 改善了老年患者的认知功能,与全身麻醉 (GA) 不同. 这项研究强调了麻醉选择对LAAO程序认知结果的影响.

科学领域:

心脏病学
神经学
麻醉学

背景情况:

心内回声扫描 (ICE) 是治疗左心房塞 (LAAO) 的一种转食管回声扫描的替代方案.
在接受LAAO的老年患者中,全身麻醉可能导致认知障碍.

研究的目的:

研究麻醉方法 (GA与中度镇静 (MS)) 对接受LAAO患者的认知功能的影响.
使用一种新的数字眼动生物标志物来评估认知变化.

主要方法:

在两个中心 (GA和MS) 招收接受LAAO的患者.
使用ViewMind系统 (眼睛追踪) 评估的认知功能在治疗开始时,在治疗后6小时和45天.
眼动测试 (Go/No Go,N-Back) 评估了群体内部和群体之间的认知差异.

主要成果:

患有多发性硬化症的患者在工作记忆,处理速度和持续注意力方面显著改善 (N-Back任务).
在研究期间,GA组中没有观察到显著的认知差异.
40名患者 (每组20名) 完成了该研究.

结论:

在MS组中,与记忆相关的眼运动指标在LAAO后有所改善,但不是GA组.
在接受LAAO的老年患者中,镇静策略似乎对认知功能有不同的影响.
这项研究为使用眼运动生物标志物评估LAAO麻醉的认知效应提供了概念证明.

关键词:

麻醉,认知评估左心房附属体封闭术后妄症

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