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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
在克罗恩病中,Veillonella肠道殖民促进了C. difficile感染
Ziyu Yang1, Jilin Wang2, Yifan Chen3
1Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China.
在克罗恩病患者中,口腔细菌Veillonella可以加剧Clostridioides difficile感染 (CDI). 通过改变胆汁酸代谢,促进CDI,并突出新治疗点.
科学领域:
- 微生物学
- 胃肠病学
- 免疫学
背景情况:
- 克罗恩病是一种慢性肠道炎症疾病,目前尚无治愈方法.
- 患有克罗恩病的患者患有Clostridioides difficile感染 (CDI) 的风险较高,使他们的病情恶化.
研究的目的:
- 调查口服初生菌,特别是Veillonella在克罗恩病患者中促进CDI的作用.
- 阐明Veillonella恶化肠道炎症和CDI的机制.
主要方法:
- 在克罗恩病患者中进行前性观察性临床研究.
- 肠道炎症的动物模型.
- 胆酸代谢和输送体表达的分析 (ASBT).
- 调查Veillonella parvula脂多糖对转录因子的影响 (c-Jun,c-Fos).
主要成果:
- 在克罗恩病中,Veillonella的肠道殖民促进了CDI.
- 在小鼠中,Veillonella parvula抑制胆汁酸转运体ASBT,减少胆汁酸的再吸收.
- 增加的Veillonella含量与克罗恩病患者的胆酸代谢发生变化相关.
- 在肠道光线中增加的胆汁酸会触发C. difficile的发芽.
- V. parvula脂多糖诱导c-Jun和c-Fos,调节ASBT的表达.
结论:
- 像Veillonella这样的口服药物可以加剧诸如克罗恩病和CDI等肠道疾病.
- 这种机制涉及ASBT的抑制,导致促进C. difficile发芽的光胆酸增加.
- 这些发现为克罗恩病患者治疗CDI提供了潜在的治疗策略.
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