相关实验视频

Updated: Sep 10, 2025

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

纳米复合物水凝可整合抑制细菌和炎症,用于感染伤口的修复

Wenyun Mu¹, Yu Wang¹, Tao Liu²

¹Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institution of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an 710049, China.

Journal of controlled release : official journal of the Controlled Release Society

|August 23, 2025

概括

这项研究开发了一种装有纳米颗粒的新型水凝,用于对抗细菌感染和炎症,通过组合疗法显著加速小鼠的感染性伤口愈合.

科学领域:

生物材料科学
纳米技术
复原医学

背景情况:

细菌感染和炎症会阻碍组织再生,并使伤口恶化.
感染伤口的有效治疗需要同时解决细菌和炎症微环境的策略.

研究的目的:

开发一种多功能纳米复合水凝来治疗受感染的伤口.
研究光热疗法,疗法和基因免疫疗法的联合治疗效果.

主要方法:

合成的反感性寡核酸改性金合金纳米粒子与封装 (APDH).
将APDH装入氨酸/酸基凝 (HS@APDH) 进行持续释放.
使用808nm近红外 (NIR) 辐射来激活级联疗法.

主要成果:

在NIR照射下,HS@APDH的光热转换效率高达58°C.
通过抑制细菌代谢和清除ROS,达到99%的抗菌效果.
促进了M1到M2巨细胞的两极分化,建立了抗炎微环境.
在体内加速伤口关闭,在第9天达到99%的关闭.

结论:

这种水凝有效抑制细菌和炎症.
这种新型水凝具有加速感染性伤口修复的巨大潜力.
综合治疗方法为先进的伤口治疗提供了一个有前途的策略.

关键词:

基因免疫疗法感染伤口的修复整合性抑制细菌和炎症纳米复合物水凝光诱导热气疗法

更多相关视频

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

相关概念视频

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...