为伴侣动物提供个性化复合药物
Konstantina Chachlioutaki1, Christos Ritzoulis2, Dimitrios G Fatouros1
1Department of Pharmacy, Aristotle University of Thessaloniki 54124 Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece.
International journal of pharmaceutics
|August 23, 2025
概括
兽医现在可以用花生为物打印定制的3D药物. 这种创新方法确保准确的剂量和可口的交付个性化兽医疗.
科学领域:
- 动物医学
- 制药科学
- 三维打印技术
背景情况:
- 越来越多的人对个性化的兽医疗需要为伴侣动物量身定制的剂量形式.
- 根据重量调整,口感和灵活配方的有限可用性导致非标签药物使用和手工复合风险.
- 目前的做法在兽医中实现精确的剂量和避免辅助剂毒性方面存在挑战.
研究的目的:
- 通过半固体挤出 (SSE) 3D打印开发一个按需的兽医复合平台.
- 用花生作为一种物种喜爱的,与药物兼容的辅助剂,用于制造有味道的兽医配方.
- 制造可调节剂量,可的药物单位,用于伴侣动物.
主要方法:
- 采用半固体挤出 (SSE) 3D打印用于按需的兽医复合.
- 使用花生作为主要辅料制成粉增强基质.
- 将普得尼索隆 (PRE) 纳入矩阵,以创建可调节剂量的可单元.
主要成果:
- 成功打印的可单元具有强大的挤出特性和优异的剂量线性 (R2 > 0.99).
- 达到即时释放药物和适合自愿口服的机械性质.
- 在冷藏条件下,印刷配方的稳定性超过14天.
结论:
- 推出了一个可扩展的3D打印平台,以改善兽医药物护理.
- 验证了基于花生的配方在伴侣动物中提供个性化药物.
- 这项技术在为慢性兽医治疗提供精确,可口和灵活的剂量方面具有潜力.
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