对疑似尾炎患者的直肠微生物组进行前性队列研究
Siv Fonnes1, Sarah Mollerup2, Sarah Juel Paulsen2
1Centre for Perioperative Optimisation, Department of Surgery, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark.
Clinics and research in hepatology and gastroenterology
|August 23, 2025
概括
肠直肠微生物组似乎不是一个有用的尾炎或其严重性的诊断工具. 分析显示尾炎患者和没有尾炎患者的微生物组合相似.
科学领域:
- 胃肠病学
- 微生物学
- 外科诊断
背景情况:
- 诊断尾炎可能是一个挑战.
- 传染病因表明微生物组可能提供诊断信号.
- 临床试验.gov 标识:NCT03349814.
研究的目的:
- 研究疑似尾炎患者的直肠微生物组的诊断潜力.
- 确定微生物组信号是否可以区分尾炎和非尾炎病例.
- 评估微生物组组成是否与尾炎的严重程度相关 (不复杂或复杂).
主要方法:
- 对怀疑尾炎的丹麦成年患者进行前性观察队列研究.
- 使用枪支基因组学分析的直肠抽样.
- 根据组织病理 (尾炎或无尾炎) 和手术结果 (无并发性或复杂性尾炎) 分类的患者.
主要成果:
- 分析了220名患者的直肠抽样 (49名无尾炎,111名无并发尾炎,60名有并发尾炎).
- 没有观察到患者群体间的α多样性或β多样性的显著差异.
- 在所有群体中发现相似的细菌属和物种的相对丰富性.
结论:
- 在患有尾炎和没有尾炎的患者中,直肠微生物组的组成相似.
- 在手术前,直肠微生物组似乎没有诊断尾炎或其严重性的潜力.
相关概念视频
Appendicitis-II: Diagnostic Studies and Management
145
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
145
Appendicitis-I: Introduction
620
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
620
Assessment of the Rectum and Anus
400
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
400
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
171
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
171
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
419
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
419


