在心力衰竭中 Sarcopenia 和 Sarcopenic 肥胖症之间的患病率和预后差异
Yule Hu1, Yan Li2, Huiying Ma3
1School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China; School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, NO.9 Dong Dan San Tiao, 100730, Beijing, China.
The American journal of cardiology
|August 23, 2025
概括
住院的心力衰竭患者通常患有缩症和缩性肥胖症,增加再入院和死亡风险. 保持肌肉质量, 不仅减少脂肪, 可能是改善结果和理解心力衰竭中的肥胖悖论的关键.
科学领域:
- 心脏病学
- 老年病学
- 营养科学
背景情况:
- 在入院心力衰竭 (HF) 患者,特别是年轻人群中,有限的证据直接比较了sarcopenia和sarcopenic肥胖症.
- 了解人体组成的作用对于解决HF肥胖悖论至关重要.
研究的目的:
- 在住院HF患者中研究皮症和皮性肥胖症的患病率和临床特征.
- 为了比较肉症和肉性肥胖症对不良结果的预后影响.
- 识别保护性身体组成的表型,并提供对HF肥胖悖论的见解.
主要方法:
- 从2022年6月到2023年10月进行的前性队列研究,共有216名参与者.
- 主要终点:与HF相关的再入院1年或因任何原因的死亡率. 二次结果:长时间住院和90天的不良反应.
- 多变量逻辑回归和考克斯比例危险回归分析了人体组成和结果之间的关联.
主要成果:
- 麻症的发病率为26. 4%,而麻症的肥胖率为19. 4%. 在这两组中,营养不良是常见的 (分别为77. 2%和71. 4%).
- 这两种类型的肥胖症独立预测了1年HF相关的再入院或全因死亡率 (HR=2. 048和HR=1. 932).
- 肥胖症也独立预测了长时间住院 (OR=2. 418).
结论:
- 住院的HF患者容易患上肉症,肉性肥胖症以及同时存在的营养不良和肥胖症.
- 肌肉质量,而不是脂肪质量,可能提供保护作用,可能解释HF肥胖悖论.
- 干预措施应侧重于减少肥胖,同时保持或增加肌肉质量.
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