长期暴露于双和帕拉本与儿童肠道微生物群之间的关联
Lourdes Rodrigo1, Carlo Bressa2, Mar Larrosa3
1Department of Legal Medicine, Toxicology and Physical Anthropology, Faculty of Medicine, University of Granada, 18012, Granada, Spain; Institute of Nutrition and Food Technology "Jose Mataix Verdú", Biomedical Research Center, Health Sciences Technological Park, University of Granada, 18016, Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain.
Environmental research
|August 23, 2025
概括
研究了儿童早期暴露于内分泌干扰化学物质,如双和类. 虽然整体肠道微生物群的多样性没有受到影响,但特定的微生物属和功能与这些化学物质接触有关.
科学领域:
- 环境健康
- 微生物组研究
- 儿童毒理学
背景情况:
- 双和是消费品中常见的内分泌干扰化学物质 (EDC).
- 早期接触EDC与不良健康结果有关.
- 慢性EDC暴露对儿童肠道微生物群的影响尚不清楚.
研究的目的:
- 调查长期接触双和与儿童肠道微生物群的多样性,组成和功能之间的关联.
- 确定受早期EDC暴露影响的特定微生物种群和代谢途径.
主要方法:
- 在97名西班牙儿童 (年龄在4-12岁) 的横截面研究中.
- 使用UHPLC-MS/MS对头发中的双和对进行量化.
- 通过PICRUSt2进行16S rRNA基因测序和功能推断来分析肠道微生物群.
- 使用线性回归和随机森林模型进行统计分析.
主要成果:
- 在所有参与者中检测到双和.
- 在低暴露组和高暴露组之间没有发现肠道微生物群的整体多样性.
- 特定的微生物属 (例如,Lachnospiraceae_UCG- 001) 和预测的功能途径 (例如,甲胺代谢) 与个体EDC暴露有关.
结论:
- 尽管整体多样性没有变化,但慢性早期接触双和可能会微妙地改变儿童的肠道微生物组成和功能.
- 这些发现强调需要进一步研究EDC暴露对发育中的肠道微生物群的健康影响.
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