超传播和老化和与年龄相关的斑点退化中的视力:ALSTAR2的纵向数据
Will Johnston1, Sarah S Kim2, Deepayan Kar2
1Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL; University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL.
American journal of ophthalmology
|August 23, 2025
概括
大型超传播区域 (LHyperTD) 在正常老化和早期的AMD中不常见,但会影响视力. 这些区域随着年龄的增长而恶化,影响视觉功能.
科学领域:
- 眼科 眼科
- 视网膜成像
- 斑点退化研究
背景情况:
- 超传播 (HT) 是一种在胸膜中的发现.
- 年龄相关的黄斑退化 (AMD) 影响中心视力.
- 对于早期检测和治疗而言,了解AMD中的胆道变化至关重要.
研究的目的:
- 调查正常衰老,早期AMD和中间AMD中超传播 (HT) 的流行情况.
- 在三年内评估HT的变化.
- 确定大HTs (LHyperTD,≥250μm) 对视觉功能测试的影响.
主要方法:
- 这项前性队列研究 (ALSTAR2) 涉及460名参与者.
- 使用光谱域光连贯断层扫描 (OCTA) 和 fundus 摄影.
- 在基线和3年随访期间进行视力测试 (scotopic, mesopic, photopic).
主要成果:
- 在基线时,HT存在于86. 7%的iAMD,35. 1%的eAMD和3. 8%的正常眼睛中.
- 在正常眼睛和iAMD眼睛中,LHyperTD的患病率在3年内增加.
- 患有LHyperTD的眼睛在基线和随访时表现出较差的光视对比度敏感性,中视对比度敏感性和棒介导的黑暗适应性.
结论:
- 大型超传播区域 (LHyperTD) 在正常和eAMD中是罕见的,但与中视和视野障碍相关.
- 延迟的棒介导黑暗适应可能受到LHyperTD以外的因素的影响.
- LHyperTD作为中期AMD后期的成像生物标志物.
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