在克里米亚 - 刚果出血热中死亡率的关键预测因素:回顾性多中心队列研究
Deniz Güllü1, Defne Yigci2, Nurcan Baykam3
1Koç University, School of Medicine - Istanbul, Türkiye; Koç University, Graduate School of Health Sciences - Istanbul, Türkiye; Koç University İşbank Center for Infectious Diseases (KUISCID) - Istanbul, Türkiye.
概括
年龄和糖尿病是克里米亚-刚果出血热 (CCHF) 死亡的关键预测因素. 早期的利巴维林治疗可能会改善CCHF患者的生存率.
科学领域:
- 传染性疾病
- 流行病学
- 公共卫生
背景情况:
- 克里米亚 - 刚果出血热 (CCHF) 是一种传播的病毒性疾病,死亡率很高.
- 确定死亡率预测因素对于有效的患者管理和资源分配至关重要.
- 了解土耳其CCHF患者的人口和临床特征对于区域卫生战略至关重要.
研究的目的:
- 在土耳其住院的克里米亚 - 刚果出血热 (CCHF) 患者中确定死亡的关键预测因素.
- 描述CCHF患者的人口统计和临床情况.
- 评估早期利巴维林给药对患者CCHF结局的影响.
主要方法:
- 对土耳其18家医院的1103名实验室确诊的CCHF患者 (2019-2024) 的回顾性研究.
- 通过在线系统收集的数据,包括人口,临床和治疗信息.
- 统计分析包括单变量和时间依赖的考克斯回归以确定死亡预测因素.
主要成果:
- 这项研究包括1103名心血管疾病患者;死亡率为5. 1% (56/1103).
- 年龄≥50岁 (OR=3. 1) 和糖尿病 (OR=4. 49) 是增加死亡率的显著预测因素.
- 早期使用利巴维林 (≤96小时) 与死亡率显著降低相关 (aHR=0. 21).
结论:
- 年龄和糖尿病等并发症是CCHF患者死亡率的重要预测因素.
- 早期识别高风险患者和及时干预对于改善结果至关重要.
- 早期使用利巴维林可降低CCHF相关的死亡率.
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